Tag: Panel Design

Evidence-Based Pan-Hematopoietic NGS Gene Panel

Evidence-Based Pan-Hematopoietic NGS Gene Panel

Using Mastermind to automate the design of a pan-hematopoietic malignancy gene panel, Dr. Mark Kiel generated a set of biomarker candidates that includes 314 genes associated with leukemia and 311 genes associated with lymphoma. Each of these candidate biomarker genes were manually annotated based on likely mechanism of pathogenesis including mutation, expression, copy number and … Continue reading Evidence-Based Pan-Hematopoietic NGS Gene Panel

Automated Panel Design at PMWC Duke

Automated Panel Design at PMWC Duke

Genomenon will be attending the Precision Medicine World Conference (PMWC17) on May 24-25 in Durham, North Carolina. Dr. Mark Kiel and Dr. Victor Weigman will be presenting a session on Automating Evidence-based Gene Panel Designs on Wednesday at 9:30 AM. The program will highlight an approach that leverages indexing millions of full text genomic articles … Continue reading Automated Panel Design at PMWC Duke

Late Breaking Research Poster at AACR: An Automated Approach to Gene Panel Design

Late Breaking Research Poster at AACR: An Automated Approach to Gene Panel Design

Dr. Victor Weigman, Director of Translational Genomics at Q2 Solutions, Dr. Matthew Schu, Senior Bioinformatician at Q2 Solutions and Dr. Mark Kiel, CSO and Founder of Genomenon will present a late-breaking research poster at AACR.  The poster is titled "An Automated Approach to Identifying Disease-Gene Associations from the Medical Literature to Inform Gene Panel Design." In the … Continue reading Late Breaking Research Poster at AACR: An Automated Approach to Gene Panel Design

Evidence-Based Gene Panel Design – There Has to be a Better Way

Evidence-Based Gene Panel Design – There Has to be a Better Way

Rational Panel Design Can Leverage Disease-Gene-Variant Associations Found in Literature. Clinicians and researchers face a daunting task when developing gene panels for any particular disease. Many times, gene panels are designed over a number of months by committee and laborious searches for evidence on which genes, exons and hotspots to include in the panel. Given … Continue reading Evidence-Based Gene Panel Design – There Has to be a Better Way